MTO1

Across TCGA pan-cancer cohorts, MTO1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MTO1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MTO1 RNA is repressed in tumor relative to normal tissue. In most cancer types MTO1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and HNSC are the cancer types where MTO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.351	<.001	10	view →
KICH	Female	II,III,IV	−1.438	<.001	9	view →
HNSC	Male	III,IV	+0.489	<.001	8	view →
KIRP	Male	All	−0.430	<.001	4	view →
LIHC	All	All	+0.258	.002	4	view →
COAD	All	II,III,IV	+0.204	.001	4	view →
STAD	All	II,III,IV	+0.384	.007	3	view →
UCEC	All	IV	−0.664	.006	2	view →
LUSC	All	All	+0.211	.001	2	view →
PRAD	All	All	−0.175	.039	2	view →
BLCA	Male	IV	−0.260	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MTO1–THCA

Open the THCA breakdown →