MTO1

Across TCGA cell cohorts, MTO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,276 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTO1-associated GO terms across cancer lineages are Mitochondrial tRNA wobble uridine modification, Nucleocytoplasmic transport, and Regulation of formation of translation preinitiation complex. Each is linked with MTO1 in more than 18 cancer types. Because this analysis shows association rather than direction, both MTO1-to-partner and partner-to-MTO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial tRNA wobble uridine modification grouped by MTO1-low versus MTO1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTO1→partner) and Y-score (partner→MTO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Mitochondrial tRNA wobble uridine modification →	+0.172	+0.815	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Nucleocytoplasmic transport →	+0.064	+0.850	.005	.001	3	12
SKIN	Regulation of formation of translation preinitiation complex →	+0.082	+0.585	.002	<.001	3	12
SKIN	Negative regulation of formation of translation preinitiation complex →	+0.082	+0.585	.002	<.001	3	12
LARGE_INTESTINE	Ribosomal large subunit assembly →	+0.116	+0.859	<.001	<.001	3	12
BREAST	Glutaminyl-tRNAGln biosynthesis via transamidation →	+0.087	+0.627	.003	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,276 associations by consensus.

Mitochondrial tRNA wobble uridine modification by MTO1 expression — LUNG_NSCLC_LUSC

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