MTO1

Across TCGA cell cohorts, MTO1 mutation is significantly associated with the drug of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTO1-associated genes across cancer lineages are Niraparib, VSP34_8731, and CCT007093. Each is linked with MTO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTO1-to-partner and partner-to-MTO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by MTO1-low versus MTO1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTO1→partner) and Y-score (partner→MTO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.430	+2.646	.014	.047	3	1
LARGE_INTESTINE	VSP34_8731 →	+0.399	+2.649	.048	.046	3	1
LARGE_INTESTINE	CCT007093 →	+0.349	+2.649	.018	.046	1	1
LARGE_INTESTINE	CDK9_5576 →	+0.534	+2.649	.041	.046	1	1
LARGE_INTESTINE	CDK9_5038 →	+0.628	+2.906	.022	.033	1	1
LARGE_INTESTINE	Carmustine →	+0.354	+2.649	.044	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Niraparib by MTO1 expression — LARGE_INTESTINE

Explore this box plot interactively →