MTNR1A

Across TCGA patient cohorts, MTNR1A mutation is significantly associated with the RNA expression of many other genes, with 1,453 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTNR1A-associated genes across cancer lineages are DVL2, MYO19, and DUXAP3. Each is linked with MTNR1A in more than 2 cancer types. Because this analysis shows association rather than direction, both MTNR1A-to-partner and partner-to-MTNR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DVL2 grouped by MTNR1A-low versus MTNR1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTNR1A→partner) and Y-score (partner→MTNR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DVL2 →	+0.467	+2.136	.002	.009	3	3
UCEC	MYO19 →	+0.521	+2.024	<.001	.005	3	3
BLCA	DUXAP3 →	+0.140	+4.683	<.001	.001	3	2
UCEC	INTS4 →	+0.306	+2.526	.003	.001	3	2
UCEC	CHEK1 →	+0.743	+1.758	<.001	.004	3	2
UCEC	CENPU →	+0.607	+2.158	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,453 associations by consensus.

DVL2 by MTNR1A expression — UCEC

Explore this box plot interactively →