MTND5P12

Across TCGA pan-cancer cohorts, MTND5P12 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MTND5P12’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MTND5P12 RNA is repressed in tumor relative to normal tissue. In most cancer types MTND5P12 is over-expressed in tumor, although a few such as LUSC and KIRP show the opposite, repressed pattern.

LUSC, KIRP, and UCEC are the cancer types where MTND5P12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTND5P12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.086	<.001	5	view →
KIRP	Female	II,III,IV	−0.114	.006	4	view →
UCEC	All	All	−0.189	.041	2	view →
PAAD	Male	All	−0.065	.005	2	view →
KICH	All	II,III,IV	+0.039	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MTND5P12–LUSC

Open the LUSC breakdown →