Q-omics provides the consensus-scored MTND4P22 profile across patient tissues and cancer cell-line models. MTND4P22 expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in LUSC. Additionally, MTND4P22 RNA expression shows 7,136 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight LUSC, and GBM as cancer lineages where MTND4P22 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes MTND4P22 survival associations across molecular data types. MTND4P22 RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

MTND4P22 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	14	LUSC (36)	view →

This table ranks reproducible MTND4P22 RNA expression–survival associations across cancer types. High MTND4P22 expression shows unfavorable associations in LUSC, COAD, KICH, PCPG and SKCM, but favorable associations in READ. The LUSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .003). Together, the overview and detailed table identify LUSC as the clearest survival context for MTND4P22 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	II,III,IV	0.314	0.625	.003	36	view →
COAD	OS	Tertile	III,IV	0.054	0.793	<.001	18	view →
KICH	DFS	Tertile	III,IV	0.043	0.897	.045	18	view →
PCPG	DFS	Tertile	All	0.495	0.897	<.001	18	view →
READ	DFS	Tertile	All	1.000	0.476	.037	18	view →
SKCM	DFS	Tertile	II,III,IV	0.317	0.602	.008	15	view →

Pink = unfavorable, green = favorable. all 14 lineages →

MTND4P22-LUSC (DFS)

Kaplan–Meier survival curve for MTND4P22 RNA expression in LUSC: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with MTND4P22 in patient tissues and cancer cell lines. In patient samples, MTND4P22 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Protein (mass-spec)	7,136	GBM (3078)	view →
Function (RNA)	5,396	STAD (4463)	view →