Across TCGA pan-cancer cohorts, MTND4LP7 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MTND4LP7’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where MTND4LP7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MTND4LP7 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
COAD and THCA are the cancer types where MTND4LP7 tumor–normal differential expression is most reproducible.