Across TCGA pan-cancer cohorts, MTND4LP21 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MTND4LP21’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where MTND4LP21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MTND4LP21 is over-expressed in tumor.
KICH are the cancer types where MTND4LP21 tumor–normal differential expression is most reproducible.