MTMR8

Across TCGA patient cohorts, MTMR8 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTMR8-associated genes across cancer lineages are Caspase-8, GAPDH, and Notch1. Each is linked with MTMR8 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTMR8-to-partner and partner-to-MTMR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by MTMR8-low versus MTMR8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR8→partner) and Y-score (partner→MTMR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.178	-1.880	.034	.014	3	3
UCEC	GAPDH →	+0.405	+1.584	.024	.034	3	2
UCEC	Notch1 →	+0.158	+2.335	<.001	.002	3	2
UCEC	Tuberin →	+0.291	+1.584	.001	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.645	+2.434	.001	.001	3	2
UCEC	cIAP →	+0.092	+1.495	.046	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Caspase-8 by MTMR8 expression — UCEC

Explore this box plot interactively →