MTMR8

Across TCGA pan-cancer cohorts, MTMR8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MTMR8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MTMR8 RNA is repressed in tumor relative to normal tissue. In most cancer types MTMR8 is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where MTMR8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTMR8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−0.533	<.001	10	view →
KICH	Male	All	−0.801	<.001	9	view →
LIHC	All	All	+0.265	<.001	8	view →
THCA	All	All	−0.179	<.001	7	view →
BLCA	Male	III,IV	−0.785	<.001	6	view →
BRCA	All	III,IV	−0.484	<.001	6	view →
KIRC	All	All	−0.242	<.001	6	view →
CHOL	All	All	+0.657	<.001	5	view →
LUSC	Male	III,IV	−0.775	.009	2	view →
PRAD	All	All	−0.582	<.001	2	view →
KIRP	Male	All	−0.303	.001	2	view →
LUAD	Female	II,III,IV	−0.244	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MTMR8–HNSC

Open the HNSC breakdown →