MTMR8

Across TCGA cell cohorts, MTMR8 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTMR8-associated genes across cancer lineages are HMGXB4, TMCO5A, and NPY2R. Each is linked with MTMR8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR8-to-partner and partner-to-MTMR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGXB4 grouped by MTMR8-low versus MTMR8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR8→partner) and Y-score (partner→MTMR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HMGXB4 →	+0.600	+3.067	.005	.009	3	1
LARGE_INTESTINE	TMCO5A →	+0.013	+3.415	<.001	.001	3	1
LARGE_INTESTINE	NPY2R →	+0.004	+3.310	<.001	<.001	3	1
LARGE_INTESTINE	QRFPR →	+0.773	+3.040	<.001	.002	3	1
LARGE_INTESTINE	LCE1F →	+0.091	+3.415	<.001	.001	3	1
SKIN	CNTNAP5 →	+0.054	+3.766	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

HMGXB4 by MTMR8 expression — LARGE_INTESTINE

Explore this box plot interactively →