MTMR12

Across TCGA patient cohorts, MTMR12 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTMR12-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with MTMR12 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTMR12-to-partner and partner-to-MTMR12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MTMR12-low versus MTMR12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR12→partner) and Y-score (partner→MTMR12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.069	-2.088	.021	.016	3	2
UCEC	EGFR_pY1068 →	-0.264	-2.050	<.001	<.001	3	2
UCEC	A-Raf_pS299 →	-0.140	-2.321	<.001	<.001	3	2
COAD	JNK_pT183_Y185 →	-0.254	-3.000	.038	.035	3	2
UCEC	Notch1 →	+0.141	+1.378	<.001	.008	3	2
UCEC	p21 →	+0.135	+2.428	.018	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

14-3-3_beta by MTMR12 expression — UCEC

Explore this box plot interactively →