MTMR12

Across TCGA pan-cancer cohorts, MTMR12 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MTMR12’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where MTMR12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MTMR12 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

LIHC, BRCA, and CHOL are the cancer types where MTMR12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTMR12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+0.590	<.001	8	view →
BRCA	Female	All	−0.415	<.001	6	view →
CHOL	All	All	+1.403	<.001	5	view →
KICH	All	All	−0.671	<.001	5	view →
COAD	All	II,III,IV	+0.296	.001	5	view →
LUAD	All	II,III,IV	−0.353	.008	4	view →
BLCA	Male	IV	−0.969	.004	2	view →
UCEC	All	All	−0.903	<.001	2	view →
READ	All	III,IV	+0.674	.018	2	view →
HNSC	All	III,IV	+0.427	.041	2	view →
LUAD	All	IV	+0.365	.026	2	view →
KIRP	Male	All	−0.320	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

MTMR12–LIHC

Open the LIHC breakdown →