MTMR12

Across TCGA cell cohorts, MTMR12 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. CNS shows the largest number of these associations.

The most reproducible MTMR12-associated genes across cancer lineages are TOPAZ1, OR5AK2, and CENPVL1. Each is linked with MTMR12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR12-to-partner and partner-to-MTMR12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOPAZ1 grouped by MTMR12-low versus MTMR12-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR12→partner) and Y-score (partner→MTMR12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TOPAZ1 →	+0.028	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR5AK2 →	+0.562	+5.369	<.001	.004	3	1
OESOPHAGUS	CENPVL1 →	+0.246	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	BMP15 →	+0.023	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	SPATA19 →	+0.197	+4.452	<.001	.001	3	1
BLOOD_Lymphoma	IQCF5 →	+0.092	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

TOPAZ1 by MTMR12 expression — SOFT_TISSUE

Explore this box plot interactively →