MTMR10

Across TCGA cell cohorts, MTMR10 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible MTMR10-associated genes across cancer lineages are MDFIC2, TBL1Y, and MMP26. Each is linked with MTMR10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR10-to-partner and partner-to-MTMR10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDFIC2 grouped by MTMR10-low versus MTMR10-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR10→partner) and Y-score (partner→MTMR10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MDFIC2 →	+0.026	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
LARGE_INTESTINE	MMP26 →	+0.048	+4.217	<.001	.001	3	1
LARGE_INTESTINE	REG1B →	+2.507	+4.196	<.001	.002	3	1
BLOOD_Leukemia	PIGY →	+2.854	+4.551	<.001	.004	3	1
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MDFIC2 by MTMR10 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →