MTM1

Across TCGA patient cohorts, MTM1 mutation is significantly associated with the RNA expression of many other genes, with 4,611 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTM1-associated genes across cancer lineages are RBPJP6, FERMT3, and HOMER1. Each is linked with MTM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTM1-to-partner and partner-to-MTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBPJP6 grouped by MTM1-low versus MTM1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTM1→partner) and Y-score (partner→MTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RBPJP6 →	+0.032	+4.730	<.001	.005	3	3
UCEC	FERMT3 →	+0.556	+1.970	<.001	<.001	3	2
UCEC	HOMER1 →	+0.476	+1.595	<.001	.002	3	2
UCEC	NMRAL1 →	+0.247	+2.565	.004	<.001	3	2
UCEC	PWWP3A →	+0.347	+1.451	<.001	<.001	3	2
UCEC	TBC1D24 →	+0.262	+1.324	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,611 associations by consensus.

RBPJP6 by MTM1 expression — LUAD

Explore this box plot interactively →