MTIF3

Across TCGA cell cohorts, MTIF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,923 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTIF3-associated GO terms across cancer lineages are Negative regulation of hematopoietic stem cell differentiation, Retrograde transport, vesicle recycling within Golgi, and DNA replication proofreading. Each is linked with MTIF3 in more than 14 cancer types. Because this analysis shows association rather than direction, both MTIF3-to-partner and partner-to-MTIF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hematopoietic stem cell differentiation grouped by MTIF3-low versus MTIF3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTIF3→partner) and Y-score (partner→MTIF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of hematopoietic stem cell differentiation →	+0.177	+1.110	<.001	<.001	2	15
STOMACH	Retrograde transport, vesicle recycling within Golgi →	+0.100	+0.564	.002	.006	3	10
OESOPHAGUS	DNA replication proofreading →	-0.132	-0.710	.003	.009	3	9
OESOPHAGUS	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.124	-1.237	.004	.003	3	9
KIDNEY	Nucleosome disassembly →	-0.144	-0.595	.001	<.001	3	9
BLOOD_Myeloma	Transcription elongation by RNA polymerase I →	-0.122	-0.467	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,923 associations by consensus.

Negative regulation of hematopoietic stem cell differentiation by MTIF3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →