MTIF3

Across TCGA pan-cancer cohorts, MTIF3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MTIF3 data layer compared with 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher MTIF3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MTIF3 expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

MESO, KIRC, and BLCA are the cancer types where MTIF3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.512	0.267	<.001	112	view →
KIRC	OS	Tertile	All	0.705	0.511	<.001	52	view →
BLCA	OS	Median	II,III,IV	0.683	0.542	.002	52	view →
UVM	DFS	Tertile	All	0.334	0.766	.004	50	view →
READ	DFS	Median	III,IV	0.575	0.912	.001	36	view →
ACC	DFS	Tertile	All	0.198	0.742	<.001	31	view →
KICH	DFS	Median	II,III,IV	0.567	0.924	.003	31	view →
CESC	DFS	Median	IV	0.218	0.713	<.001	24	view →
THYM	OS	Median	II,III,IV	1.000	0.882	.007	15	view →
KIRP	OS	Quartile	All	0.935	0.807	.014	15	view →
PCPG	DFS	Tertile	All	1.000	0.797	.006	15	view →
THCA	OS	Tertile	III,IV	1.000	0.311	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MTIF3–MESO (OS)

Open the MESO breakdown →