MTHFD2L

Across TCGA patient cohorts, MTHFD2L RNA expression is significantly associated with the go_rna of many other GO terms, with 7,168 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MTHFD2L-associated GO terms across cancer lineages are Positive regulation of post-translational protein modification, Regulation of chromatin organization, and tRNA processing. Each is linked with MTHFD2L in more than 30 cancer types. Because this analysis shows association rather than direction, both MTHFD2L-to-partner and partner-to-MTHFD2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of post-translational protein modification grouped by MTHFD2L-low versus MTHFD2L-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD2L→partner) and Y-score (partner→MTHFD2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Positive regulation of post-translational protein modification →	+0.047	+0.380	.004	.001	3	30
UVM	Regulation of chromatin organization →	+0.059	+0.740	<.001	<.001	3	29
UVM	tRNA processing →	+0.045	+0.779	<.001	<.001	3	29
LAML	Aspartate family amino acid biosynthetic process →	+0.071	+0.908	<.001	<.001	3	29
LAML	Methionine biosynthetic process →	+0.078	+0.880	<.001	<.001	3	29
SCLC	Centriole assembly →	+0.079	+0.728	.003	<.001	1	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,168 associations by consensus.

Positive regulation of post-translational protein modification by MTHFD2L expression — ESCA

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