MTHFD2L

Across TCGA cell cohorts, MTHFD2L RNA expression is significantly associated with the RNA expression of many other genes, with 10,075 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MTHFD2L-associated genes across cancer lineages are THAP6, PAQR3, and ZRANB2. Each is linked with MTHFD2L in more than 11 cancer types. Because this analysis shows association rather than direction, both MTHFD2L-to-partner and partner-to-MTHFD2L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MTHFD2L versus THAP6 in LUNG_SCLC, with a Pearson correlation of 0.51.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD2L→partner) and Y-score (partner→MTHFD2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	THAP6 →	+0.767	+0.937	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	PAQR3 →	+1.064	+0.950	<.001	<.001	3	11
BLOOD_Lymphoma	ZRANB2 →	+0.989	+0.710	.001	.002	3	10
LUNG_SCLC	SMARCAD1 →	+0.926	+0.843	<.001	<.001	1	12
UPPER_AERODIGESTIVE_TRACT	CCDC66 →	+0.952	+0.933	<.001	<.001	3	9
BLOOD_Lymphoma	PPAT →	+1.207	+0.939	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,075 associations by consensus.

MTHFD2L vs THAP6 — LUNG_SCLC

Explore this scatter interactively →