MTHFD2

Across TCGA patient cohorts, MTHFD2 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,017 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MTHFD2-associated proteins across cancer lineages are KPNA2, RRM2, and SMC2. Each is linked with MTHFD2 in more than 8 cancer types. Because this analysis shows association rather than direction, both MTHFD2-to-partner and partner-to-MTHFD2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MTHFD2 versus KPNA2 in BRCA, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD2→partner) and Y-score (partner→MTHFD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KPNA2 →	+0.709	+0.630	<.001	<.001	3	9
LUAD	RRM2 →	+0.815	+0.794	<.001	<.001	3	8
UCEC	SMC2 →	+0.652	+0.864	<.001	<.001	3	8
UCEC	SMC4 →	+0.627	+0.872	<.001	<.001	3	8
LUAD	CDC20_T70 →	+1.285	+0.773	<.001	<.001	3	8
LUAD	CDK1 →	+0.881	+0.688	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,017 associations by consensus.

MTHFD2 vs KPNA2 — BRCA

Explore this scatter interactively →