MTHFD1L

Across TCGA patient cohorts, MTHFD1L protein abundance is significantly associated with the RNA expression of many other genes, with 14,834 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MTHFD1L-associated genes across cancer lineages are ARL4AP5, PGM5, and JAM2. Each is linked with MTHFD1L in more than 7 cancer types. Because this analysis shows association rather than direction, both MTHFD1L-to-partner and partner-to-MTHFD1L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MTHFD1L versus ARL4AP5 in UCEC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD1L→partner) and Y-score (partner→MTHFD1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARL4AP5 →	+0.724	+0.475	<.001	<.001	3	8
UCEC	PGM5 →	-1.132	-0.320	.002	.008	3	7
UCEC	JAM2 →	-0.705	-0.341	.005	.006	2	8
BRCA	TCEAL3 →	-0.801	-0.682	<.001	<.001	3	7
BRCA	SLC7A5 →	+1.645	+0.744	<.001	<.001	3	6
UCEC	CPED1 →	-0.732	-0.314	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,834 associations by consensus.

MTHFD1L vs ARL4AP5 — UCEC

Explore this scatter interactively →