MTHFD1L

Across TCGA pan-cancer cohorts, MTHFD1L RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MTHFD1L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MTHFD1L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MTHFD1L is over-expressed in tumor.

COAD, HNSC, and BLCA are the cancer types where MTHFD1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTHFD1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+3.136	<.001	12	view →
HNSC	Female	IV	+2.406	<.001	12	view →
BLCA	Male	III,IV	+2.281	<.001	12	view →
STAD	Male	II,III,IV	+2.450	<.001	11	view →
KIRP	All	III,IV	+1.522	<.001	11	view →
THCA	Male	All	+1.258	<.001	10	view →
LIHC	Female	II,III,IV	+1.747	<.001	9	view →
LUAD	Male	III,IV	+1.435	<.001	9	view →
KIRC	Male	All	+0.832	<.001	9	view →
LUSC	Male	III,IV	+2.025	<.001	8	view →
READ	All	All	+2.032	<.001	7	view →
UCEC	All	III,IV	+1.277	.004	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MTHFD1L–COAD

Open the COAD breakdown →