MTHFD1L

Across TCGA patient cohorts, MTHFD1L mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTHFD1L-associated genes across cancer lineages are ATM, STAT3_pY705, and JNK_pT183_Y185. Each is linked with MTHFD1L in more than 2 cancer types. Because this analysis shows association rather than direction, both MTHFD1L-to-partner and partner-to-MTHFD1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MTHFD1L-low versus MTHFD1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD1L→partner) and Y-score (partner→MTHFD1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.586	-2.263	<.001	<.001	3	3
UCEC	STAT3_pY705 →	-0.431	-2.060	<.001	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.228	-2.249	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.121	-2.209	.013	.009	3	2
UCEC	PDCD4 →	-0.434	-1.392	.005	.019	3	2
UCEC	PKC-delta_pS664 →	-0.090	-2.321	.022	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by MTHFD1L expression — UCEC

Explore this box plot interactively →