MTHFD1L

Across TCGA cell cohorts, MTHFD1L RNA expression is significantly associated with the go_rna of many other GO terms, with 3,525 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MTHFD1L-associated GO terms across cancer lineages are Formate metabolic process, Formate biosynthetic process, and Tetrahydrofolate biosynthetic process. Each is linked with MTHFD1L in more than 19 cancer types. Because this analysis shows association rather than direction, both MTHFD1L-to-partner and partner-to-MTHFD1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Formate metabolic process grouped by MTHFD1L-low versus MTHFD1L-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD1L→partner) and Y-score (partner→MTHFD1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Formate metabolic process →	+0.229	+1.645	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Formate biosynthetic process →	+0.207	+1.427	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Tetrahydrofolate biosynthetic process →	+0.193	+1.270	<.001	<.001	3	19
STOMACH	Embryonic neurocranium morphogenesis →	+0.236	+1.190	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Tetrahydrofolate interconversion →	+0.154	+0.817	<.001	<.001	3	17
KIDNEY	Dicarboxylic acid biosynthetic process →	+0.301	+0.928	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,525 associations by consensus.

Formate metabolic process by MTHFD1L expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →