MTHFD1L

Across TCGA cell cohorts, MTHFD1L mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTHFD1L-associated genes across cancer lineages are TRHR, MYPN, and OR10C1. Each is linked with MTHFD1L in more than 1 cancer types. Because this analysis shows association rather than direction, both MTHFD1L-to-partner and partner-to-MTHFD1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRHR grouped by MTHFD1L-low versus MTHFD1L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD1L→partner) and Y-score (partner→MTHFD1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRHR →	+0.052	+3.839	<.001	.001	3	2
BLOOD_Leukemia	MYPN →	+0.034	+4.152	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.066	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR12D1 →	+0.042	+4.887	<.001	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.343	+3.252	<.001	.009	3	1
LARGE_INTESTINE	CPLX4 →	+0.030	+3.222	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TRHR by MTHFD1L expression — LARGE_INTESTINE

Explore this box plot interactively →