MTHFD1

Across TCGA patient cohorts, MTHFD1 mutation is significantly associated with the RNA expression of many other genes, with 1,854 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTHFD1-associated genes across cancer lineages are RNU1-17P, MTATP6P21, and RNU7-11P. Each is linked with MTHFD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTHFD1-to-partner and partner-to-MTHFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by MTHFD1-low versus MTHFD1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD1→partner) and Y-score (partner→MTHFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU1-17P →	+0.219	+4.588	<.001	.008	3	3
UCEC	MTATP6P21 →	+0.223	+1.797	<.001	.005	3	3
LIHC	RNU7-11P →	+0.625	+5.355	<.001	.005	3	2
SKCM	MRPS5 →	+0.386	+3.591	.005	.001	3	2
SKCM	BAG3 →	+0.524	+3.198	.005	.009	3	2
SKCM	PSMG3 →	+0.610	+3.591	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,854 associations by consensus.

RNU1-17P by MTHFD1 expression — BLCA

Explore this box plot interactively →