Across TCGA pan-cancer cohorts, MTCYBP22 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MTCYBP22’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MTCYBP22 RNA is repressed in tumor relative to normal tissue. In most cancer types MTCYBP22 is over-expressed in tumor, although a few such as KIRC and STAD show the opposite, repressed pattern.
KIRC and STAD are the cancer types where MTCYBP22 tumor–normal differential expression is most reproducible.