Across TCGA patient cohorts, MTCP1 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTCP1-associated genes across cancer lineages are RNU7-161P, RNA5SP321, and SNORD109B. Each is linked with MTCP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTCP1-to-partner and partner-to-MTCP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTCP1→partner) and Y-score (partner→MTCP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU7-161P →	+0.348	+4.137	<.001	.008	3	2
LUSC	RNA5SP321 →	+0.611	+4.984	<.001	.009	3	2
SKCM	SNORD109B →	+0.575	+5.469	<.001	.002	3	1
SKCM	GOLGA2P6 →	+0.027	+6.219	<.001	<.001	3	1
SKCM	RNA5SP384 →	+0.347	+4.867	<.001	.005	3	1
SKCM	RNU7-77P →	+0.579	+4.268	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

MTCP1 survival (RNA) · tumor vs normal (RNA) · all MTCP1 data types