MTCO2P21

Across TCGA patient cohorts, MTCO2P21 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,550 significant associations in total. STAD shows the largest number of these associations.

The most reproducible MTCO2P21-associated GO terms across cancer lineages are Protein localization to vacuole, Glycerophospholipid biosynthetic process, and Intracellular pH reduction. Each is linked with MTCO2P21 in more than 14 cancer types. Because this analysis shows association rather than direction, both MTCO2P21-to-partner and partner-to-MTCO2P21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to vacuole grouped by MTCO2P21-low versus MTCO2P21-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTCO2P21→partner) and Y-score (partner→MTCO2P21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Protein localization to vacuole →	+0.080	+0.120	<.001	<.001	3	15
STAD	Glycerophospholipid biosynthetic process →	+0.067	+0.134	<.001	<.001	3	15
STAD	Intracellular pH reduction →	+0.054	+0.118	<.001	<.001	3	15
STAD	Transcription initiation at RNA polymerase II promoter →	+0.067	+0.133	<.001	<.001	3	15
STAD	tRNA processing →	+0.069	+0.116	<.001	<.001	3	15
STAD	Positive regulation of proteasomal protein catabolic process →	+0.070	+0.118	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,550 associations by consensus.

Protein localization to vacuole by MTCO2P21 expression — STAD

Explore this box plot interactively →