MTCL1

Across TCGA patient cohorts, MTCL1 mutation is significantly associated with the total protein of many other genes, with 92 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MTCL1-associated genes across cancer lineages are Shc_pY317, p62 Lck ligand, and EGFR_pY1068. Each is linked with MTCL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MTCL1-to-partner and partner-to-MTCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by MTCL1-low versus MTCL1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTCL1→partner) and Y-score (partner→MTCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Shc_pY317 →	-0.162	-2.321	.039	.034	3	4
UCEC	p62 Lck ligand →	+0.223	+1.536	.017	.002	3	4
STAD	EGFR_pY1068 →	-0.355	-3.321	.041	.009	3	3
STAD	RAD51 →	+0.255	+2.321	.011	.034	3	3
LUAD	Bim →	+0.564	+2.321	<.001	.035	3	3
LUAD	Cyclin-E1 →	+0.302	+3.000	.013	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

Shc_pY317 by MTCL1 expression — STAD

Explore this box plot interactively →