MTCL1

Across TCGA pan-cancer cohorts, MTCL1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MTCL1 data layer compared with 9 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MTCL1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MTCL1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

UVM, MESO, and ACC are the cancer types where MTCL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.369	0.822	<.001	127	view →
MESO	OS	Median	All	0.415	0.661	<.001	126	view →
ACC	OS	Quartile	II,III,IV	0.183	1.000	.001	45	view →
CESC	OS	Median	All	0.484	0.672	.003	40	view →
LUAD	OS	Median	All	0.768	0.849	.005	28	view →
HNSC	OS	Quartile	All	0.591	0.820	.007	25	view →
LIHC	OS	Median	All	0.416	0.602	.001	23	view →
KICH	OS	Quartile	II,III,IV	0.337	0.913	.004	22	view →
SKCM	DFS	Median	All	0.676	0.831	.001	22	view →
BRCA	OS	Quartile	III,IV	0.687	0.391	.013	16	view →
BLCA	DFS	Median	All	0.683	0.568	.022	13	view →
SARC	OS	Tertile	All	0.496	0.816	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MTCL1–UVM (DFS)

Open the UVM breakdown →