MTCL1

Across TCGA cell cohorts, MTCL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,665 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MTCL1-associated GO terms across cancer lineages are Protein depolymerization, Cell division, and Positive regulation of focal adhesion assembly. Each is linked with MTCL1 in more than 11 cancer types. Because this analysis shows association rather than direction, both MTCL1-to-partner and partner-to-MTCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein depolymerization grouped by MTCL1-low versus MTCL1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTCL1→partner) and Y-score (partner→MTCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Protein depolymerization →	+0.092	+1.081	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Cell division →	+0.073	+1.534	.006	.007	3	12
BONE	Positive regulation of focal adhesion assembly →	+0.197	+2.832	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Negative regulation of Rho protein signal transduction →	+0.183	+1.554	.001	.003	3	12
BONE	Regulation of hippo signaling →	+0.108	+2.486	<.001	.005	3	12
BONE	Regulation of early endosome to late endosome transport →	+0.118	+2.128	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,665 associations by consensus.

Protein depolymerization by MTCL1 expression — CNS

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