MTAP

Across TCGA patient cohorts, MTAP protein abundance is significantly associated with the RNA expression of many other genes, with 8,576 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MTAP-associated genes across cancer lineages are CDKN2A, DMRTA1, and KLHL9. Each is linked with MTAP in more than 6 cancer types. Because this analysis shows association rather than direction, both MTAP-to-partner and partner-to-MTAP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MTAP versus CDKN2A in GBM, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTAP→partner) and Y-score (partner→MTAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDKN2A →	+3.049	+0.881	<.001	<.001	3	7
GBM	DMRTA1 →	+0.912	+0.680	<.001	<.001	3	7
GBM	KLHL9 →	+1.423	+0.773	<.001	<.001	3	7
GBM	ERVFRD-3 →	+0.974	+1.023	<.001	<.001	3	7
HNSC	CDC37L1 →	+0.618	+0.824	<.001	<.001	3	6
GBM	CDKN2B →	+2.523	+0.777	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,576 associations by consensus.

MTAP vs CDKN2A — GBM

Explore this scatter interactively →