MTAP

Across TCGA patient cohorts, MTAP mutation is significantly associated with the RNA expression of many other genes, with 2,595 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTAP-associated genes across cancer lineages are RNU6-1034P, RNA5SP413, and RPPH1-3P. Each is linked with MTAP in more than 1 cancer types. Because this analysis shows association rather than direction, both MTAP-to-partner and partner-to-MTAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1034P grouped by MTAP-low versus MTAP-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTAP→partner) and Y-score (partner→MTAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1034P →	+0.459	+5.337	<.001	.006	3	2
LUAD	RNA5SP413 →	+0.188	+7.930	<.001	.008	3	2
LUAD	RPPH1-3P →	+0.069	+7.930	<.001	.008	3	2
UCEC	IGHV1-69D →	+1.530	+2.403	.001	<.001	3	1
UCEC	ARRDC3-AS1 →	+0.198	+2.732	.009	.003	3	1
UCEC	MMP12 →	+1.009	+3.480	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,595 associations by consensus.

RNU6-1034P by MTAP expression — LUSC

Explore this box plot interactively →