MTA3

Across TCGA patient cohorts, MTA3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,642 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MTA3-associated genes across cancer lineages are MSH2, MSH6, and CPSF3. Each is linked with MTA3 in more than 6 cancer types. Because this analysis shows association rather than direction, both MTA3-to-partner and partner-to-MTA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MTA3 versus MSH2 in LSCC, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTA3→partner) and Y-score (partner→MTA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MSH2 →	+0.917	+0.487	<.001	<.001	3	7
LSCC	MSH6 →	+0.824	+0.458	<.001	<.001	3	6
LSCC	CPSF3 →	+0.682	+0.503	<.001	<.001	3	6
HNSC	PPM1G →	+0.828	+0.329	<.001	<.001	3	5
LSCC	SELENOI →	+0.894	+0.350	<.001	<.001	3	5
LSCC	SPPL3 →	+0.552	+0.432	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,642 associations by consensus.

MTA3 vs MSH2 — LSCC

Explore this scatter interactively →