MTA3

Across TCGA patient cohorts, MTA3 mutation is significantly associated with the RNA expression of many other genes, with 416 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTA3-associated genes across cancer lineages are RNU6-1245P, SERBP1P2, and MIR3663. Each is linked with MTA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTA3-to-partner and partner-to-MTA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1245P grouped by MTA3-low versus MTA3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTA3→partner) and Y-score (partner→MTA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1245P →	+0.335	+3.765	<.001	.007	3	3
SKCM	SERBP1P2 →	+0.025	+4.495	.009	.007	3	3
SKCM	MIR3663 →	+0.485	+3.993	<.001	.005	3	2
LUSC	RNA5SP205 →	+0.358	+6.733	<.001	<.001	3	2
LUSC	CDRT15P2 →	+0.129	+5.706	.001	.003	3	2
LUSC	SNRPGP7 →	+0.428	+5.474	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 416 associations by consensus.

RNU6-1245P by MTA3 expression — SKCM

Explore this box plot interactively →