MT3

Across TCGA patient cohorts, MT3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MT3-associated genes across cancer lineages are PRDX1, JNK_pT183_Y185, and p90 RSK. Each is linked with MT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MT3-to-partner and partner-to-MT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by MT3-low versus MT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT3→partner) and Y-score (partner→MT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.241	+2.459	.015	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.171	-3.000	.035	.036	3	1
UCEC	p90 RSK →	+0.209	+3.179	.023	.010	3	1
UCEC	ATM →	-0.460	-3.584	.035	.002	3	1
UCEC	C-Raf_pS338 →	-0.100	-2.950	.011	.036	3	1
UCEC	JNK2 →	+0.216	+3.584	.024	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PRDX1 by MT3 expression — UCEC

Explore this box plot interactively →