MT3

Across TCGA pan-cancer cohorts, MT3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MT3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MT3 RNA is repressed in tumor relative to normal tissue. In most cancer types MT3 is over-expressed in tumor, although a few such as KIRP and HNSC show the opposite, repressed pattern.

KIRP, LIHC, and HNSC are the cancer types where MT3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	III,IV	−1.647	<.001	11	view →
LIHC	All	All	+0.632	<.001	7	view →
HNSC	All	All	−0.599	.001	7	view →
STAD	All	II,III,IV	−0.482	<.001	7	view →
UCEC	All	All	+1.976	<.001	6	view →
KIRC	Male	All	+1.163	<.001	6	view →
BRCA	Female	II,III,IV	+0.162	.002	6	view →
KICH	All	All	+1.741	.001	5	view →
COAD	Male	All	−0.880	.001	4	view →
BLCA	Female	III,IV	−0.311	.020	4	view →
THCA	Male	All	−0.298	.013	3	view →
LUSC	All	All	+0.374	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MT3–KIRP

Open the KIRP breakdown →