MT1L

Across TCGA patient cohorts, MT1L mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MT1L-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and CD4+ memory T-cells. Each is linked with MT1L in more than 1 cancer types. Because this analysis shows association rather than direction, both MT1L-to-partner and partner-to-MT1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by MT1L-low versus MT1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT1L→partner) and Y-score (partner→MT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ T-cells →	+0.025	+3.845	.003	.004	3	1
UCEC	CD8+ Tcm →	+0.033	+2.935	.014	.046	3	1
UCEC	CD4+ memory T-cells →	+0.044	+3.885	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD8+ T-cells by MT1L expression — UCEC

Explore this box plot interactively →