MT1IP

Across TCGA pan-cancer cohorts, MT1IP RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of MT1IP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MT1IP RNA is repressed in tumor relative to normal tissue. In most cancer types MT1IP is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where MT1IP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT1IP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	−0.395	<.001	12	view →
KIRP	Female	II,III,IV	−0.776	<.001	8	view →
THCA	All	IV	−0.972	<.001	7	view →
UCEC	All	All	+0.713	<.001	6	view →
KICH	Female	All	−0.454	<.001	6	view →
COAD	Female	II,III,IV	−1.243	<.001	5	view →
BRCA	Female	All	−0.075	<.001	4	view →
READ	All	All	−0.619	.001	3	view →
LIHC	All	II,III,IV	−0.134	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

MT1IP–KIRC

Open the KIRC breakdown →