MT1B

Across TCGA patient cohorts, MT1B mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MT1B-associated genes across cancer lineages are SNORD115-42, RN7SKP223, and RBMY2NP. Each is linked with MT1B in more than 1 cancer types. Because this analysis shows association rather than direction, both MT1B-to-partner and partner-to-MT1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD115-42 grouped by MT1B-low versus MT1B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT1B→partner) and Y-score (partner→MT1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNORD115-42 →	+0.728	+7.930	<.001	.008	3	1
LUAD	RN7SKP223 →	+0.863	+7.930	<.001	.008	3	1
LUAD	RBMY2NP →	+0.044	+7.930	<.001	.008	3	1
LUAD	SOCS5P1 →	+0.049	+7.930	<.001	.008	3	1
LUAD	TRMT112P1 →	+0.244	+7.930	<.001	.008	3	1
LUSC	OR4F7P →	+0.054	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SNORD115-42 by MT1B expression — LUAD

Explore this box plot interactively →