Across TCGA pan-cancer cohorts, MT-TW RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MT-TW’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MT-TW RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MT-TW is over-expressed in tumor, although a few such as LUSC and PRAD show the opposite, repressed pattern.

KICH, STAD, and LUSC are the cancer types where MT-TW tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT-TW RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	+0.320	.009	4	view →
STAD	Male	II,III,IV	+0.315	.042	2	view →
LUSC	All	All	−0.174	.012	2	view →
PRAD	All	All	−0.092	.042	2	view →
LUAD	All	All	+0.170	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: MT-TW RNA expression & survival · all MT-TW data types