Across TCGA patient cohorts, MT-TM RNA expression is significantly associated with the go_rna of many other GO terms, with 6,929 significant associations in total. LGG shows the largest number of these associations.

The most reproducible MT-TM-associated GO terms across cancer lineages are Proton transmembrane transport, Protein maturation by [4Fe-4S] cluster transfer, and Aerobic respiration. Each is linked with MT-TM in more than 14 cancer types. Because this analysis shows association rather than direction, both MT-TM-to-partner and partner-to-MT-TM results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-TM→partner) and Y-score (partner→MT-TM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	Proton transmembrane transport →	+0.026	+1.423	<.001	<.001	3	15
GBM	Protein maturation by [4Fe-4S] cluster transfer →	+0.036	+0.315	<.001	.008	1	14
LGG	Aerobic respiration →	+0.023	+1.348	<.001	<.001	3	11
LGG	Cellular respiration →	+0.018	+1.248	<.001	<.001	3	11
LUSC	Cell redox homeostasis →	+0.024	+0.683	<.001	<.001	3	11
READ	Protein localization to presynapse →	+0.084	+2.192	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,929 associations by consensus.

Exploration

MT-TM survival (RNA) · tumor vs normal (RNA) · all MT-TM data types