Across TCGA pan-cancer cohorts, MT-TM RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MT-TM data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher MT-TM RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MT-TM expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUAD show a favorable association.

UVM, KIRC, and BLCA are the cancer types where MT-TM RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.364	0.937	<.001	113	view →
KIRC	DFS	Quartile	III,IV	0.471	0.667	.002	61	view →
BLCA	DFS	Tertile	II,III,IV	0.579	0.411	.001	53	view →
UCEC	DFS	Tertile	IV	0.266	0.702	.010	20	view →
MESO	DFS	Quartile	III,IV	0.096	0.580	.010	17	view →
PRAD	OS	Quartile	All	0.849	0.934	.002	12	view →
BRCA	DFS	Median	IV	0.289	0.708	.006	12	view →
LUAD	DFS	Quartile	III,IV	0.773	0.467	.011	10	view →
GBM	DFS	Tertile	All	0.155	0.334	.008	9	view →
PAAD	DFS	Median	All	0.511	0.230	.002	9	view →
SKCM	DFS	Median	All	0.154	0.258	.005	8	view →
ESCA	DFS	Tertile	All	0.397	0.877	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

Exploration

Same gene, other analysis: MT-TM tumor-vs-normal RNA expression · all MT-TM data types