Across TCGA pan-cancer cohorts, MT-TI RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MT-TI’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where MT-TI RNA is repressed in tumor relative to normal tissue. In most cancer types MT-TI is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.

BRCA, KIRC, and LIHC are the cancer types where MT-TI tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT-TI RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	−0.199	.023	4	view →
KIRC	Male	All	−0.219	.019	3	view →
LIHC	All	II,III,IV	+0.501	.029	2	view →
COAD	All	IV	−0.458	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MT-TI RNA expression & survival · all MT-TI data types