Across TCGA pan-cancer cohorts, MT-TH RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MT-TH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MT-TH RNA is repressed in tumor relative to normal tissue. In most cancer types MT-TH is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC and COAD are the cancer types where MT-TH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT-TH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.252	.001	8	view →
COAD	All	All	+0.936	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: MT-TH RNA expression & survival · all MT-TH data types