Across TCGA pan-cancer cohorts, MT-TF RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MT-TF data layer.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MT-TF RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MT-TF expression acts as an unfavorable survival marker, although some lineages such as KIRC and BLCA show a favorable association.
KIRC, BLCA, and LUSC are the cancer types where MT-TF RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.