Across TCGA cell cohorts, MT-ND4L mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MT-ND4L-associated genes across cancer lineages are ASZ1, PRSS38, and CYP4Z1. Each is linked with MT-ND4L in more than 1 cancer types. Because this analysis shows association rather than direction, both MT-ND4L-to-partner and partner-to-MT-ND4L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-ND4L→partner) and Y-score (partner→MT-ND4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ASZ1 →	+0.034	+2.847	.002	.009	3	1
LUNG_SCLC	PRSS38 →	+0.033	+3.794	<.001	.003	3	1
LUNG_SCLC	CYP4Z1 →	+0.178	+3.849	<.001	<.001	3	1
LUNG_SCLC	C17orf98 →	+0.074	+2.635	.001	.007	3	1
LUNG_SCLC	GSTT4 →	+0.010	+2.684	<.001	.007	3	1
LUNG_SCLC	SPINK13 →	+0.119	+3.404	.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

MT-ND4L survival (RNA) · tumor vs normal (RNA) · all MT-ND4L data types