Across TCGA pan-cancer cohorts, MT-ND4L RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MT-ND4L’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MT-ND4L RNA is repressed in tumor relative to normal tissue. In most cancer types MT-ND4L is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.
KIRC, BRCA, and KICH are the cancer types where MT-ND4L tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT-ND4L RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.